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NADH

Also indexed as: Nicotinamide Adenine Dinucleotide

Nicotinamide adenine dinucleotide (NADH) is the active coenzyme form of vitamin B3. It plays an essential role in the energy production of every human cell.

Where is it found?

NADH is found in the muscle tissue of fish and poultry and cattle, as well as in food products made with yeast. However, it is not known whether the NADH from these sources can be efficiently absorbed or utilized by the body. It is also available as a nutritional supplement.

NADH has been used in connection with the following conditions (refer to the individual health concern for complete information):

Science RatingHealth Concerns
2StarsChronic fatigue syndrome
Parkinson’s disease
1StarAlzheimer’s disease
Depression
3Stars Reliable and relatively consistent scientific data showing a substantial health benefit.
2Stars Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.
1Star For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support and/or minimal health benefit.

Who is likely to be deficient?

NADH deficiency is known to occur only in the presence of vitamin B3 deficiency, which is rare in Western society except in some alcoholics.

Which form of NADH is best?

NADH appears to be a chemically unstable molecule that decomposes rapidly. For this reason, techniques have been developed to stabilize the NADH sold in tablet form. At the present time, it is not known which commercially available NADH products are most effective.

How much is usually taken?

Researchers have used 10 mg per day, taken with water only, on an empty stomach.

Are there any side effects or interactions?

Clinical studies of NADH using oral or intravenous administration have reported no side effects with up to one year or more of use. Longer-term use has not been evaluated.

At the time of writing, there were no well-known drug interactions with NADH.

2009-01-21

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